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Tramadol may also cause seizures. The risk of seizures is increased in people who have a seizure disorder or who are taking antidepressants or other opioid (or narcotic) pain relievers. Antidepressants and other drugs that affect serotonin can lead to a potentially life-threatening reaction, serotonin syndrome, with Tramadol. Serotonin syndrome is marked by mental-status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea).This is not a complete list of the side effects or drug interactions associated with tramadol. Michelle McDermott, RPh, PharmD
Tramadol has inhibitory actions on the 5-HT2C receptor. Antagonism of 5-HT2C could be partially responsible for tramadol’s reducing effect on depressive and obsessive–compulsive symptoms in patients with pain and co-morbid neurological illnesses.[52] 5-HT2C blockade may also account for its lowering of the seizure threshold, as 5-HT2C knockout mice display significantly increased vulnerability to epileptic seizures, sometimes resulting in spontaneous death.
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