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Psychic and physical dependence can happen with tramadol use, according to its prescribing information. Tramadol should not be used in people with opioid dependence. In some people who have been previously dependent on other opioids, tramadol has been shown to reinitiate physical dependence. However, the risk of dependence and abuse — including drug-seeking behavior and attempting to get tramadol illegally — are not limited to people with a prior history of opioid dependence. People with a history of substance abuse are at a higher risk of psychic and physical dependence. Derek Dore, PharmD
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