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    According to the prescribing information, Ultram should not be given to patients who are addiction-prone or suicidal. Furthermore, Ultram should be used with caution in patients concomitantly taking tranquilizers, antidepressants, use alcohol in excess or who have been diagnosed with emotional disturbance or depression. Ultram related deaths have occurred in these populations of patients. Serotonin syndrome is possible with treatment with Ultram alone.
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