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A positron emission tomography imaging study found that single oral 50 mg and 100 mg doses of tramadol to human volunteers resulted in 34.7% and 50.2% respective mean occupation of the serotonin transporter (SERT) in the thalamus.[76] The estimated median effective dose (ED50) for SERT occupancy hence was 98.1 mg, which was associated with a plasma tramadol level of about 330 ng/mL (1,300 nM).[76] It was also estimated that the maximum daily dosage of tramadol of 400 mg (100 mg q.i.d.) would result in as much as 78.7% occupancy of the SERT (in association with a plasma concentration of 1,220 ng/mL or 4,632 nM).[76] This is close to that of selective serotonin reuptake inhibitors (SSRIs), which occupy the SERT by 80% or more.[76]
in patients being also being treated with the antibiotic linezolid, lithium or St. John’s Wort. Signs and symptoms of serotonin syndrome include mental status changes, such as agitation or hallucinations, tachycardia, fluctuating blood pressure, hyperreflexia, incoordination, fever, shivering, tremor, sweating, nausea, vomiting, diarrhea, seizures and coma. Seek immediate medical attention if you experience any signs and symptoms associated with serotonin syndrome. If you are currently taking any of the above medications, speak to your health care provider before beginning treatment with Ultram to prevent possible drug interactions and to avoid the development of serotonin syndrome.
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A positron emission tomography imaging study found that single oral 50 mg and 100 mg doses of tramadol to human volunteers resulted in 34.7% and 50.2% respective mean occupation of the serotonin transporter (SERT) in the thalamus.[76] The estimated median effective dose (ED50) for SERT occupancy hence was 98.1 mg, which was associated with a plasma tramadol level of about 330 ng/mL (1,300 nM).[76] It was also estimated that the maximum daily dosage of tramadol of 400 mg (100 mg q.i.d.) would result in as much as 78.7% occupancy of the SERT (in association with a plasma concentration of 1,220 ng/mL or 4,632 nM).[76] This is close to that of selective serotonin reuptake inhibitors (SSRIs), which occupy the SERT by 80% or more.[76]
in patients being also being treated with the antibiotic linezolid, lithium or St. John’s Wort. Signs and symptoms of serotonin syndrome include mental status changes, such as agitation or hallucinations, tachycardia, fluctuating blood pressure, hyperreflexia, incoordination, fever, shivering, tremor, sweating, nausea, vomiting, diarrhea, seizures and coma. Seek immediate medical attention if you experience any signs and symptoms associated with serotonin syndrome. If you are currently taking any of the above medications, speak to your health care provider before beginning treatment with Ultram to prevent possible drug interactions and to avoid the development of serotonin syndrome.
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