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Before taking this medicine You should not use Topamax if you are allergic to topiramate. To make sure Topamax is safe for you, tell your doctor if you have: glaucoma or other eye problems; diabetes, or a history of metabolic acidosis; kidney disease, a history of kidney stones, or if you are on dialysis; severe breathing problems; a history of mood problems, depression, or suicidal thoughts or actions; liver disease; soft or brittle bones (osteoporosis, osteomalacia); a growth disorder; if you take lithium; or if you are sick with diarrhea.
Topiramate is quickly absorbed after oral use. Most of the drug (70%) is excreted in the urine unchanged. The remainder is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation. Six metabolites have been identified in humans, none of which constitutes more than 5% of an administered dose. Take topiramate exactly as your doctor tells you to. It is usual to start topiramate treatment on a low dose (25 mg at night), and then for the dose to be increased gradually. A usual maintenance dose is 50-100 mg daily, taken either as a single dose or divided into two doses over the day.
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