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The seizure risk is also increased in patient taking Ultram concomitantly with selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) or other tricyclic medications, such as cyclobenzaprine or promethazine, other opioids, monoamine oxidase inhibitors (MAOIs), neuroleptics or other medications that reduce the seizure threshold. The risk of convulsions may also be increased in patients with epilepsy, a history of seizures, or in patients who already have a risk for seizures, such as head trauma. There is also a suicide risk possible with Ultram treatment.
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