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Mechanism Of Action. ALDACTONE (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.
According to the low effective arterial volume and the extrarenal loss of sodium, aldosterone secretion increased. … However, during episodes of intestinal loss of sodium the spironolactone-induced impairment of aldosterone-mediated resorption of sodium can cause a life-threatening hyponatremia.

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