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Q: Does tramadol aggravate the liver?A: Tramadol (Ultram) is a medication used to treat moderate to moderately severe pain. Tramadol is an opioid-like analgesic. The metabolism of tramadol is reduced in patients with liver dysfunction. It is recommended to decrease the dose of tramadol in patients with liver problems. Some of the most common side effects associated with tramadol include flushing, dizziness, headache, drowsiness, insomnia, itching, constipation, nausea, vomiting, upset stomach and weakness. The prescribing information for tramadol does list hepatitis and liver failure as rare potential side effects. Tramadol can affect the ability to perform tasks that require mental alertness such as driving, do not drive or operate machinery until you know how tramadol will affect you. Alcohol should be avoided in patients taking tramadol. Alcohol can increase the side effects of tramadol and alcohol also has negative effects on the liver.
…in many cases of tramadol dependence, a history of substance abuse is present….but….the evidence for physical dependence was considered minimal. Consequently, Tramadol is generally considered as a drug with low potential for dependence. In a recent German study (including a literature study, an analysis of two drug safety databases, and questionnaires analyses), the low abuse and low dependence potential of Tramadol were re-confirmed. The German expert group found a low prevalence of abuse or dependence in clinical practice in Germany, and concluded that Tramadol has a low potential for misuse, abuse, and dependence in Germany.[30]
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