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If the side effects cause anxiety, it is necessary to see a doctor. DisclaimerInformation provided in this article is meant for the personal familiarization only and does not impel for the action. You have to realize all responsibility while taking strong medical products and use them by doctor’s recommendations only. The designers of this website are not responsible for the provided information and consequences which may happen while taking strong medical products.
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However, other studies have found that the analgesic effects of tramadol are significantly decreased or even absent in CYP2D6 poor metabolizers.[11][67] The analgesic effects of tramadol are only partially reversed by naloxone in human volunteers,[11] hence indicating that its opioid action is unlikely the sole factor; tramadol’s analgesic effects are also partially reversed by α2-adrenergic receptor antagonists like yohimbine, the 5-HT3 receptor antagonist ondansetron, and the 5-HT7 receptor antagonists SB-269970 and SB-258719.[13][83] Pharmacologically, tramadol is similar to tapentadol and methadone in that it not only binds to the MOR, but also inhibits the reuptake of serotonin and norepinephrine[3] due to its action on the noradrenergic and serotonergic systems, such as its “atypical” opioid activity.[84]
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