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However, the reduction of seizure threshold could be attributed to tramadol’s putative inhibition of GABAA receptors at high doses (significant inhibition at 100 μM).[61][65] In addition, desmetramadol is a high-affinity ligand of the DOR, and activation of this receptor could be involved in tramadol’s ability to provoke seizures in some individuals, as DOR agonists are well known for inducing seizures.[46]
It is difficult to say if it will be “safe” for you individually over an extended period of time. Patients react differently to medications. According to medical references, the most common adverse effects occurring in greater than 10% of studied patients taking tramadol include the following: flushing, dizziness, headache, somnolence, insomnia, pruritus (itching), constipation, nausea, vomiting, dyspepsia (upset stomach) and weakness. These are not all of the possible side effects associated with the use of tramadol. The recommendation is made for you to talk to your physician regarding the questions and concerns that you have about using tramadol for an extended period of time. Jen Marsico, RPh
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However, the reduction of seizure threshold could be attributed to tramadol’s putative inhibition of GABAA receptors at high doses (significant inhibition at 100 μM).[61][65] In addition, desmetramadol is a high-affinity ligand of the DOR, and activation of this receptor could be involved in tramadol’s ability to provoke seizures in some individuals, as DOR agonists are well known for inducing seizures.[46]
It is difficult to say if it will be “safe” for you individually over an extended period of time. Patients react differently to medications. According to medical references, the most common adverse effects occurring in greater than 10% of studied patients taking tramadol include the following: flushing, dizziness, headache, somnolence, insomnia, pruritus (itching), constipation, nausea, vomiting, dyspepsia (upset stomach) and weakness. These are not all of the possible side effects associated with the use of tramadol. The recommendation is made for you to talk to your physician regarding the questions and concerns that you have about using tramadol for an extended period of time. Jen Marsico, RPh
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