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The pump acts to re-absorb sodium and water in exchange for potassium, which is then eliminated in the urine. Consequently, aldosterone antagonism can cause hyperkalemia. Hyperkalemia is an established adverse effect of both spironolactone and eplerenone. The symptoms of hyperkalemia begin with muscle weakness.
According to the low effective arterial volume and the extrarenal loss of sodium, aldosterone secretion increased. … However, during episodes of intestinal loss of sodium the spironolactone-induced impairment of aldosterone-mediated resorption of sodium can cause a life-threatening hyponatremia.
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The pump acts to re-absorb sodium and water in exchange for potassium, which is then eliminated in the urine. Consequently, aldosterone antagonism can cause hyperkalemia. Hyperkalemia is an established adverse effect of both spironolactone and eplerenone. The symptoms of hyperkalemia begin with muscle weakness.
According to the low effective arterial volume and the extrarenal loss of sodium, aldosterone secretion increased. … However, during episodes of intestinal loss of sodium the spironolactone-induced impairment of aldosterone-mediated resorption of sodium can cause a life-threatening hyponatremia.

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