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Contraindications. You should not take Pradaxa if you are allergic to dabigatran, or if you have an artificial heart valve or any active bleeding from a surgery, injury, or other cause. Pradaxa may cause you to bleed more easily, especially if you have a stomach ulcer; you have recent or recurring bleeding in your stomach or intestines; you have kidney disease (especially if you also take dronedarone or ketoconazole); you take certain other medicines that can increase bleeding risk such as aspirin, clopidogrel (Plavix), heparin, prasugrel, warfarin (Coumadin, Jantoven); you take an NSAID (nonsteroidal anti-inflammatory drug) on a regular basis, such as ibuprofen (Advil, Motrin), naproxen (Aleve), diclofenac, indomethacin, meloxicam, and others; or you are older than 75.
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